No proof of tumorigenicity was noticed in male and woman mice at codeine dietary doses around four hundred mg/kg/working day (close to comparable to forty five situations the MRHD on the mg/m2 foundation).

The drug is excreted largely while in the urine, mostly as inactive metabolites and modest quantities of cost-free and conjugated morphine. Negligible amounts of codeine and its metabolites are located in the feces.

Prescription drug abuse is definitely the intentional non-therapeutic usage of a prescription drug, even at the time, for its fulfilling psychological or physiological effects.

When offered concomitantly with promethazine, the dose of barbiturates really should be decreased by no less than just one-fifty percent, as well as the dose of narcotics ought to be decreased by a person-quarter to 1-half. Dosage have to be individualized. Extreme amounts of promethazine HCl relative to your narcotic may well cause restlessness and motor hyperactivity within the client with soreness; these indications typically disappear with satisfactory Charge of the soreness.

When utilized for an extended time, this medication may not get the job done at the same time and will require distinctive dosing. Speak with your health practitioner if this medication stops Functioning properly.

Pregnancy Exams: Diagnostic pregnancy exams depending on immunological reactions in between HCG and anti-HCG could lead to Wrong-damaging or Phony-constructive interpretations.

The next critical adverse reactions are explained, or explained in greater detail, in other sections:

Should the reaction to an opioid antagonist is suboptimal or only brief in mother nature, administer additional antagonist as directed from the merchandise’s prescribing information and facts. The respiratory depressant outcomes of promethazine are certainly not reversed by opioid antagonists, including naloxone.

The combination of promethazine hydrochloride and codeine phosphate really should be made use of with warning in pediatric people 6 many years and more mature (see Warnings-Use in Pediatric Patients).

If adrenal insufficiency is diagnosed, address Promethazine codeine syrup with physiologic replacement doses of corticosteroids. Wean the patient off in the opioid to allow adrenal operate to Get better and go on corticosteroid therapy until adrenal function recovers. Other opioids can be tried out as some instances noted utilization of a distinct opioid without having recurrence of adrenal insufficiency. The knowledge accessible isn't going to identify any individual opioids as currently being a lot more likely to be related to adrenal insufficiency.

The dosage is based on your age, health-related issue, and reaction to treatment method. Carefully measure the dose employing a Distinctive measuring unit/spoon. Never make use of a household spoon because you may not get the proper dose.

Respiration difficulties (respiratory melancholy)that may lead to Demise and opioid withdrawal can happen if You begin having or prevent having other medicines though using Promethazine Hydrochloride and Codeine Phosphate Oral Answer, which includes:

As a result of inconsistencies concerning the drug labels on DailyMed plus the tablet pictures provided by RxImage, we no more Screen the RxImage capsule visuals affiliated with drug labels.

When physicians prescribe codeine-made up of prescription drugs, they ought to choose the least expensive successful dose with the shortest period of time and may advise their sufferers about these dangers and also the indications of morphine overdose (see Safeguards - Nursing Mothers).